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Amino-acid site variability among natural and designed proteins

Computational protein design attempts to create protein sequences that fold stably into pre-specified structures. Here we compare alignments of designed proteins to alignments of natural proteins and assess how closely designed sequences recapitulate patterns of sequence variation found in natural p...

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Detalles Bibliográficos
Autores principales: Jackson, Eleisha L., Ollikainen, Noah, Covert, Arthur W., Kortemme, Tanja, Wilke, Claus O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828621/
https://www.ncbi.nlm.nih.gov/pubmed/24255821
http://dx.doi.org/10.7717/peerj.211