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Amino-acid site variability among natural and designed proteins
Computational protein design attempts to create protein sequences that fold stably into pre-specified structures. Here we compare alignments of designed proteins to alignments of natural proteins and assess how closely designed sequences recapitulate patterns of sequence variation found in natural p...
Autores principales: | Jackson, Eleisha L., Ollikainen, Noah, Covert, Arthur W., Kortemme, Tanja, Wilke, Claus O. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PeerJ Inc.
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828621/ https://www.ncbi.nlm.nih.gov/pubmed/24255821 http://dx.doi.org/10.7717/peerj.211 |
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