Single site-specific integration targeting coupled with embryonic stem cell differentiation provides a high-throughput alternative to in vivo enhancer analyses

Comprehensive analysis of cis-regulatory elements is key to understanding the dynamic gene regulatory networks that control embryonic development. While transgenic animals represent the gold standard assay, their generation is costly, entails significant animal usage, and in utero development compli...

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Detalles Bibliográficos
Autores principales: Wilkinson, Adam C., Goode, Debbie K., Cheng, Yi-Han, Dickel, Diane E., Foster, Sam, Sendall, Tim, Tijssen, Marloes R., Sanchez, Maria-Jose, Pennacchio, Len A., Kirkpatrick, Aileen M., Göttgens, Berthold
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828770/
https://www.ncbi.nlm.nih.gov/pubmed/24244860
http://dx.doi.org/10.1242/bio.20136296

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828770/
https://www.ncbi.nlm.nih.gov/pubmed/24244860
http://dx.doi.org/10.1242/bio.20136296

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