Selective Inhibition of the Master Regulator Transcription Factor Egr‐1 With Catalytic Oligonucleotides Reduces Myocardial Injury and Improves Left Ventricular Systolic Function in a Preclinical Model of Myocardial Infarction

BACKGROUND: Egr‐1 is implicated in the pathogenesis of myocardial ischemia–reperfusion injury. The aim of this study was to ascertain the effectiveness of intracoronary delivery of DNAzyme targeting the transcription factor Egr‐1 at reperfusion following experimental myocardial ischemia. METHODS AND...

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Detalles Bibliográficos
Autores principales: Rayner, Benjamin S., Figtree, Gemma A., Sabaretnam, Tharani, Shang, Ping, Mazhar, Jawad, Weaver, James C., Lay, William N., Witting, Paul K., Hunyor, Stephen N., Grieve, Stuart M., Khachigian, Levon M., Bhindi, Ravinay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828787/
https://www.ncbi.nlm.nih.gov/pubmed/23902638
http://dx.doi.org/10.1161/JAHA.113.000023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828787/
https://www.ncbi.nlm.nih.gov/pubmed/23902638
http://dx.doi.org/10.1161/JAHA.113.000023

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