Loss of Apelin Exacerbates Myocardial Infarction Adverse Remodeling and Ischemia‐reperfusion Injury: Therapeutic Potential of Synthetic Apelin Analogues

BACKGROUND: Coronary artery disease leading to myocardial ischemia is the most common cause of heart failure. Apelin (APLN), the endogenous peptide ligand of the APJ receptor, has emerged as a novel regulator of the cardiovascular system. METHODS AND RESULTS: Here we show a critical role of APLN in...

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Detalles Bibliográficos
Autores principales: Wang, Wang, McKinnie, Shaun M.K., Patel, Vaibhav B., Haddad, George, Wang, Zuocheng, Zhabyeyev, Pavel, Das, Subhash K., Basu, Ratnadeep, McLean, Brent, Kandalam, Vijay, Penninger, Josef M., Kassiri, Zamaneh, Vederas, John C., Murray, Allan G., Oudit, Gavin Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828798/
https://www.ncbi.nlm.nih.gov/pubmed/23817469
http://dx.doi.org/10.1161/JAHA.113.000249

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828798/
https://www.ncbi.nlm.nih.gov/pubmed/23817469
http://dx.doi.org/10.1161/JAHA.113.000249

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