Hypotension Due to Kir6.1 Gain‐of‐Function in Vascular Smooth Muscle

BACKGROUND: K(ATP) channels, assembled from pore‐forming (Kir6.1 or Kir6.2) and regulatory (SUR1 or SUR2) subunits, link metabolism to excitability. Loss of Kir6.2 results in hypoglycemia and hyperinsulinemia, whereas loss of Kir6.1 causes Prinzmetal angina–like symptoms in mice. Conversely, overact...

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Detalles Bibliográficos
Autores principales: Li, Anlong, Knutsen, Russell H., Zhang, Haixia, Osei‐Owusu, Patrick, Moreno‐Dominguez, Alex, Harter, Theresa M., Uchida, Keita, Remedi, Maria S., Dietrich, Hans H., Bernal‐Mizrachi, Carlos, Blumer, Kendall J., Mecham, Robert P., Koster, Joseph C., Nichols, Colin G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828800/
https://www.ncbi.nlm.nih.gov/pubmed/23974906
http://dx.doi.org/10.1161/JAHA.113.000365

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828800/
https://www.ncbi.nlm.nih.gov/pubmed/23974906
http://dx.doi.org/10.1161/JAHA.113.000365

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