Arginase‐II Induces Vascular Smooth Muscle Cell Senescence and Apoptosis Through p66Shc and p53 Independently of Its l‐Arginine Ureahydrolase Activity: Implications for Atherosclerotic Plaque Vulnerability

BACKGROUND: Vascular smooth muscle cell (VSMC) senescence and apoptosis are involved in atherosclerotic plaque vulnerability. Arginase‐II (Arg‐II) has been shown to promote vascular dysfunction and plaque vulnerability phenotypes in mice through uncoupling of endothelial nitric oxide synthase and ac...

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Detalles Bibliográficos
Autores principales: Xiong, Yuyan, Yu, Yi, Montani, Jean‐Pierre, Yang, Zhihong, Ming, Xiu‐Fen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828809/
https://www.ncbi.nlm.nih.gov/pubmed/23832324
http://dx.doi.org/10.1161/JAHA.113.000096

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828809/
https://www.ncbi.nlm.nih.gov/pubmed/23832324
http://dx.doi.org/10.1161/JAHA.113.000096

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