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Deficiency in TLR4 signal transduction ameliorates cardiac injury and cardiomyocyte contractile dysfunction during ischemia

Toll-like receptor 4 (TLR4), a proximal signalling receptor in innate immune responses to lipopolysaccharide of gram-negative pathogens, is expressed in the heart. Accumulating evidence have consolidated the notion that TLR4 plays an essential role in the pathogenesis of cardiac dysfunction. However...

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Detalles Bibliográficos
Autores principales: Zhao, Peng, Wang, Jingying, He, Leilei, Ma, Heng, Zhang, Xiaoyu, Zhu, Xinglei, Dolence, E Kurt, Ren, Jun, Li, Ji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828863/
https://www.ncbi.nlm.nih.gov/pubmed/19508385
http://dx.doi.org/10.1111/j.1582-4934.2009.00798.x