U2OS cells lacking Chk1 undergo aberrant mitosis and fail to activate the spindle checkpoint

Chk1 is a conserved protein kinase originally identified in fission yeast, required to delay entry of cells with damaged or unreplicated DNA into mitosis. The requirement of Chk1 for both S and G2/M checkpoints has been elucidated while only few studies have connected Chk1 to the mitotic spindle che...

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Detalles Bibliográficos
Autores principales: Carrassa, Laura, Sanchez, Yolanda, Erba, Eugenio, Damia, Giovanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2009
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828867/
https://www.ncbi.nlm.nih.gov/pubmed/19778378
http://dx.doi.org/10.1111/j.1582-4934.2008.00362.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828867/
https://www.ncbi.nlm.nih.gov/pubmed/19778378
http://dx.doi.org/10.1111/j.1582-4934.2008.00362.x

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