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Activation of TGF-β within cultured hepatocytes and in liver injury leads to intracrine signaling with expression of connective tissue growth factor

Recently, synthesis and secretion of connective tissue growth factor (CTGF)/CYR61/CTGF/NOV-family member 2 (CCN2) in cultures of hepatocytes were shown, which are sensitively up-regulated by exogenous TGF-β. In this study TGF-β-dependent CTGF/CCN2 expression in hepatocytes cultured under completely...

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Detalles Bibliográficos
Autores principales: Gressner, Olav A, Lahme, Birgit, Siluschek, Monika, Rehbein, Katharina, Herrmann, Jens, Weiskirchen, Ralf, Gressner, Axel M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828886/
https://www.ncbi.nlm.nih.gov/pubmed/18266973
http://dx.doi.org/10.1111/j.1582-4934.2008.00260.x