Cargando…

Unfolded protein response suppresses CEBPA by induction of calreticulin in acute myeloid leukaemia

The unfolded protein response (UPR) is triggered by the accumulation of misfolded proteins within the endoplasmic reticulum (ER). The role of the UPR during leukemogenesis is unknown so far. Here, we studied the induction of mediators of the UPR in leukaemic cells of AML patients. Increased expressi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schardt, Julian A, Eyholzer, Marianne, Timchenko, Nikolai A, Mueller, Beatrice U, Pabst, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2010
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829017/ https://www.ncbi.nlm.nih.gov/pubmed/19659458 http://dx.doi.org/10.1111/j.1582-4934.2009.00870.x

Ejemplares similares

Heterogeneity within AML with CEBPA mutations; only CEBPA double mutations, but not single CEBPA mutations are associated with favourable prognosis
por: Pabst, T, et al.
Publicado: (2009)

The tumour-suppressive miR-29a/b1 cluster is regulated by CEBPA and blocked in human AML
por: Eyholzer, M, et al.
Publicado: (2010)

Dependence on Myb expression is attenuated in myeloid leukaemia with N-terminal CEBPA mutations
por: Volpe, Giacomo, et al.
Publicado: (2019)

Clinical relevance of mutant NPM1 and CEBPA in patients with acute myeloid leukaemia – preliminary report
por: Helbig, Grzegorz, et al.
Publicado: (2014)

Expression of CEBPA is reduced in RUNX1-mutated acute myeloid leukemia
por: Grossmann, V, et al.
Publicado: (2012)

CCAAT enhancer binding protein alpha (CEBPA) biallelic acute myeloid leukaemia: cooperating lesions, molecular mechanisms and clinical relevance
por: Wilhelmson, Anna S., et al.
Publicado: (2020)

CEBPA-regulated lncRNAs, new players in the study of acute myeloid leukemia
por: Hughes, James M, et al.
Publicado: (2014)

Germline CEBPA mutation in familial acute myeloid leukemia
por: Boada, Matilde, et al.
Publicado: (2021)

Sporadic and Familial Acute Myeloid Leukemia with CEBPA Mutations
por: Yuan, Ji, et al.
Publicado: (2023)

MiR‐486 promotes proliferation and suppresses apoptosis in myeloid cells by targeting Cebpa in vitro
por: Jiang, Jingwei, et al.
Publicado: (2018)

The value of molecular stratification for CEBPA (DM) and NPM1 (MUT) FLT3 (WT) genotypes in older patients with acute myeloid leukaemia
por: Dickson, Glenda J., et al.
Publicado: (2015)

Reply to ‘Heterogeneity within AML with CEBPA mutations; only CEBPA double mutations, but not single CEBPA mutations are associated with favorable prognosis’
por: Hou, H-A, et al.
Publicado: (2009)

Prognostic Nomogram for Acute Myeloid Leukemia Patients With Biallelic CEBPA Mutations
por: Xu, Xiaoyu, et al.
Publicado: (2021)

Acute Myeloid Leukemia With CEBPA Mutations: Current Progress and Future Directions
por: Su, Long, et al.
Publicado: (2022)

In Vivo Deletion of the Cebpa +37 kb Enhancer Markedly Reduces Cebpa mRNA in Myeloid Progenitors but Not in Non-Hematopoietic Tissues to Impair Granulopoiesis
por: Guo, Hong, et al.
Publicado: (2016)

Two Novel CEBPA Mutations in a Turkish Patient with Acute Myeloid Leukemia
por: Tokgun, PE, et al.
Publicado: (2021)

The regulatory control of Cebpa enhancers and silencers in the myeloid and red-blood cell lineages
por: Repele, Andrea, et al.
Publicado: (2019)

Gain-of-Function Effects of N-Terminal CEBPA Mutations in Acute Myeloid Leukemia
por: Schmidt, Luisa, et al.
Publicado: (2020)

Prognostic impact of CEBPA bZIP domain mutation in acute myeloid leukemia
por: Wakita, Satoshi, et al.
Publicado: (2022)

Acute myeloid leukemia due to germline CEBPA mutation in a Syrian family
por: Wafa, Abdulsamad, et al.
Publicado: (2022)

Induction of Resistance Against Isotransplantation of Virus-Induced Myeloid Leukaemias
por: Pasternak, G., et al.
Publicado: (1963)

In Silico Genetics Revealing 5 Mutations in CEBPA Gene Associated With Acute Myeloid Leukemia
por: Mustafa, Mujahed I, et al.
Publicado: (2019)

Identification and interrogation of the gene regulatory network of CEBPA-double mutant acute myeloid leukemia
por: Adamo, Assunta, et al.
Publicado: (2022)

Myeloid lineage enhancers drive oncogene synergy in CEBPA/CSF3R mutant acute myeloid leukemia
por: Braun, Theodore P., et al.
Publicado: (2019)

RUNX1/CEBPA Mutation in Acute Myeloid Leukemia Promotes Hypermethylation and Indicates for Demethylation Therapy
por: Romanova, Ekaterina I., et al.
Publicado: (2022)

Novel Mutations in CEBPA in Korean Patients with Acute Myeloid Leukemia with a Normal Karyotype
por: Kim, Sollip, et al.
Publicado: (2012)

Mutational Landscape of CEBPA in Mexican Pediatric Acute Myeloid Leukemia Patients: Prognostic Implications
por: Molina Garay, Carolina, et al.
Publicado: (2022)

The ASXL1-G643Wvariant accelerates the development of CEBPA mutant acute myeloid leukemia
por: D’Altri, Teresa, et al.
Publicado: (2020)

Location, location, location: A mini-review of CEBPA variants in patients with acute myeloid leukemia
por: Faisal, Muhammad Salman, et al.
Publicado: (2023)

Clinical Significance of bZIP In-Frame CEBPA-Mutated Normal Karyotype Acute Myeloid Leukemia
por: Ahn, Seo-Yeon, et al.
Publicado: (2023)

Author Correction: Myeloid lineage enhancers drive oncogene synergy in CEBPA/CSF3R mutant acute myeloid leukemia
por: Braun, Theodore P., et al.
Publicado: (2022)

The +37 kb Cebpa Enhancer Is Critical for Cebpa Myeloid Gene Expression and Contains Functional Sites that Bind SCL, GATA2, C/EBPα, PU.1, and Additional Ets Factors
por: Cooper, Stacy, et al.
Publicado: (2015)

Calreticulin mediates immune recognition of acute myeloid leukemia cells in vivo
por: Chen, Xiufen, et al.
Publicado: (2013)

CD7 in acute myeloid leukemia: correlation with loss of wild-type CEBPA, consequence of epigenetic regulation
por: Röhrs, Sonja, et al.
Publicado: (2010)

CEBPA mutations in patients with de novo acute myeloid leukemia: data analysis in a Chinese population
por: Su, Long, et al.
Publicado: (2016)

Association between the CEBPA and c-MYC genes expression levels and acute myeloid leukemia pathogenesis and development
por: Krygier, Adrian, et al.
Publicado: (2020)

Calreticulin and the Heart
por: Groenendyk, Jody, et al.
Publicado: (2022)

Acute Myeloid Leukaemia in Its Niche: the Bone Marrow Microenvironment in Acute Myeloid Leukaemia
por: Ladikou, E. E., et al.
Publicado: (2020)

Chemotherapy of the Myeloid Leukaemias
por: Stuart, John
Publicado: (1980)

Diallyl disulfide down‐regulates calreticulin and promotes C/EBPα expression in differentiation of human leukaemia cells
por: Sun, Jing, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_3r3j3u2735mhqlusbred90uas8