Fusion of the C-terminal triskaidecapeptide of hirudin variant 3 to alpha1-proteinase inhibitor M358R increases the serpin-mediated rate of thrombin inhibition

BACKGROUND: Alpha-1 proteinase inhibitor (API) is a plasma serpin superfamily member that inhibits neutrophil elastase; variant API M358R inhibits thrombin and activated protein C (APC). Fusing residues 1-75 of another serpin, heparin cofactor II (HCII), to API M358R (in HAPI M358R) was previously s...

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Detalles Bibliográficos
Autores principales: Roddick, Leigh Ann, Bhakta, Varsha, Sheffield, William P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3830444/
https://www.ncbi.nlm.nih.gov/pubmed/24215622
http://dx.doi.org/10.1186/1471-2091-14-31

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3830444/
https://www.ncbi.nlm.nih.gov/pubmed/24215622
http://dx.doi.org/10.1186/1471-2091-14-31

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