The pungent substances piperine, capsaicin, 6-gingerol and polygodial inhibit the human two-pore domain potassium channels TASK-1, TASK-3 and TRESK

For a long time, the focus of trigeminal chemoperception has rested almost exclusively on TRP channels. However, two-pore domain (K(2P)) potassium channels have recently been identified as targets for substances associated with typical trigeminal sensations, such as numbing and tingling. In addition...

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Detalles Bibliográficos
Autores principales: Beltrán, Leopoldo R., Dawid, Corinna, Beltrán, Madeline, Gisselmann, Guenter, Degenhardt, Katharina, Mathie, Klaus, Hofmann, Thomas, Hatt, Hanns
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831292/
https://www.ncbi.nlm.nih.gov/pubmed/24302912
http://dx.doi.org/10.3389/fphar.2013.00141

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831292/
https://www.ncbi.nlm.nih.gov/pubmed/24302912
http://dx.doi.org/10.3389/fphar.2013.00141

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