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The association between MTHFR 677C>T genotype and folate status and genomic and gene-specific DNA methylation in the colon of individuals without colorectal neoplasia(1)(2)(3)(4)

Background: Decreased genomic and increased gene-specific DNA methylation predispose to colorectal cancer. Dietary folate intake and the methylenetetrahydrofolate reductase polymorphism (MTHFR 677C>T) may influence risk by modifying DNA methylation. Objective: We investigated the associations bet...

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Detalles Bibliográficos
Autores principales:	Hanks, Joanna, Ayed, Iyeman, Kukreja, Neil, Rogers, Chris, Harris, Jessica, Gheorghiu, Alina, Liu, Chee Ling, Emery, Peter, Pufulete, Maria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Nutrition 2013
Materias:	Gene-Nutrient Interactions
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831541/ https://www.ncbi.nlm.nih.gov/pubmed/24108782 http://dx.doi.org/10.3945/ajcn.113.061432

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