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TusA (YhhP) and IscS are required for molybdenum cofactor-dependent base-analog detoxification

Lack of molybdenum cofactor (Moco) in Escherichia coli leads to hypersensitivity to the mutagenic and toxic effects of N-hydroxylated base analogs, such as 6-N-hydroxylaminopurine (HAP). This phenotype is due to the loss of two Moco-dependent activities, YcbX and YiiM, that are capable of reducing H...

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Detalles Bibliográficos
Autores principales: Kozmin, Stanislav G, Stepchenkova, Elena I, Schaaper, Roel M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831636/
https://www.ncbi.nlm.nih.gov/pubmed/23894086
http://dx.doi.org/10.1002/mbo3.108