Prolonged inhibition of 5-HT(3) receptors by palonosetron results from surface receptor inhibition rather than inducing receptor internalization

BACKGROUND AND PURPOSE: The 5-HT(3) receptor antagonist palonosetron is an important treatment for emesis and nausea during cancer therapy. Its clinical efficacy may result from its unique binding and clearance characteristics and receptor down-regulation mechanisms. We investigated the mechanisms b...

Descripción completa

Detalles Bibliográficos
Autores principales: Hothersall, J Daniel, Moffat, Christopher, Connolly, Christopher N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2013
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831706/
https://www.ncbi.nlm.nih.gov/pubmed/23581504
http://dx.doi.org/10.1111/bph.12204

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831706/
https://www.ncbi.nlm.nih.gov/pubmed/23581504
http://dx.doi.org/10.1111/bph.12204

Ejemplares similares