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Prolonged inhibition of 5-HT(3) receptors by palonosetron results from surface receptor inhibition rather than inducing receptor internalization

BACKGROUND AND PURPOSE: The 5-HT(3) receptor antagonist palonosetron is an important treatment for emesis and nausea during cancer therapy. Its clinical efficacy may result from its unique binding and clearance characteristics and receptor down-regulation mechanisms. We investigated the mechanisms b...

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Detalles Bibliográficos
Autores principales:	Hothersall, J Daniel, Moffat, Christopher, Connolly, Christopher N
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2013
Materias:	Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831706/ https://www.ncbi.nlm.nih.gov/pubmed/23581504 http://dx.doi.org/10.1111/bph.12204

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