Nephrin missense mutations: induction of endoplasmic reticulum stress and cell surface rescue by reduction in chaperone interactions

Nephrin, an important component of the podocyte filtration slit diaphragm, plays a key role in the maintenance of glomerular permselectivity. Mutations in nephrin lead to proteinuria and congenital nephrotic syndrome. Nephrin undergoes posttranslational modifications in the endoplasmic reticulum (ER...

Descripción completa

Detalles Bibliográficos
Autores principales: Drozdova, Tetyana, Papillon, Joan, Cybulsky, Andrey V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831901/
https://www.ncbi.nlm.nih.gov/pubmed/24303155
http://dx.doi.org/10.1002/phy2.86

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831901/
https://www.ncbi.nlm.nih.gov/pubmed/24303155
http://dx.doi.org/10.1002/phy2.86

Ejemplares similares