Roscovitine Suppresses CD4+ T Cells and T Cell-Mediated Experimental Uveitis

BACKGROUND: T cells are essential for the development of uveitis and other autoimmune diseases. After initial activation, CD4+ lymphocytes express the co-stimulatory molecule OX40 that plays an important role in T cell proliferation. Cyclin dependent kinase 2 (CdK2) plays a pivotal role in the cell...

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Detalles Bibliográficos
Autores principales: Zhang, Zili, Liu, Qi, Leskov, Konstantin S., Wu, Xiumei, Duan, Jie, Zhang, Gary L., Hall, Mark, Rosenbaum, James T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832440/
https://www.ncbi.nlm.nih.gov/pubmed/24260551
http://dx.doi.org/10.1371/journal.pone.0081154

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832440/
https://www.ncbi.nlm.nih.gov/pubmed/24260551
http://dx.doi.org/10.1371/journal.pone.0081154

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