Cargando…
Roscovitine Suppresses CD4+ T Cells and T Cell-Mediated Experimental Uveitis
BACKGROUND: T cells are essential for the development of uveitis and other autoimmune diseases. After initial activation, CD4+ lymphocytes express the co-stimulatory molecule OX40 that plays an important role in T cell proliferation. Cyclin dependent kinase 2 (CdK2) plays a pivotal role in the cell...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832440/ https://www.ncbi.nlm.nih.gov/pubmed/24260551 http://dx.doi.org/10.1371/journal.pone.0081154 |