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Roscovitine Suppresses CD4+ T Cells and T Cell-Mediated Experimental Uveitis

BACKGROUND: T cells are essential for the development of uveitis and other autoimmune diseases. After initial activation, CD4+ lymphocytes express the co-stimulatory molecule OX40 that plays an important role in T cell proliferation. Cyclin dependent kinase 2 (CdK2) plays a pivotal role in the cell...

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Detalles Bibliográficos
Autores principales:	Zhang, Zili, Liu, Qi, Leskov, Konstantin S., Wu, Xiumei, Duan, Jie, Zhang, Gary L., Hall, Mark, Rosenbaum, James T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832440/ https://www.ncbi.nlm.nih.gov/pubmed/24260551 http://dx.doi.org/10.1371/journal.pone.0081154

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