Inhibition of Leishmania (Leishmania) amazonensis and Rat Arginases by Green Tea EGCG, (+)-Catechin and (−)-Epicatechin: A Comparative Structural Analysis of Enzyme-Inhibitor Interactions

Epigallocatechin-3-gallate (EGCG), a dietary polyphenol (flavanol) from green tea, possesses leishmanicidal and antitrypanosomal activity. Mitochondrial damage was observed in Leishmania treated with EGCG, and it contributed to the lethal effect. However, the molecular target has not been defined. I...

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Detalles Bibliográficos
Autores principales: dos Reis, Matheus Balduíno Goncalves, Manjolin, Letícia Correa, Maquiaveli, Claudia do Carmo, Santos-Filho, Osvaldo Andrade, da Silva, Edson Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832641/
https://www.ncbi.nlm.nih.gov/pubmed/24260115
http://dx.doi.org/10.1371/journal.pone.0078387

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832641/
https://www.ncbi.nlm.nih.gov/pubmed/24260115
http://dx.doi.org/10.1371/journal.pone.0078387

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