Global Phosphotyrosine Proteomics Identifies PKCδ as a Marker of Responsiveness to Src Inhibition in Colorectal Cancer

Sensitive and specific biomarkers of protein kinase inhibition can be leveraged to accelerate drug development studies in oncology by associating early molecular responses with target inhibition. In this study, we utilized unbiased shotgun phosphotyrosine (pY) proteomics to discover novel biomarkers...

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Detalles Bibliográficos
Autores principales: McKinley, Eliot T., Liu, Huiling, McDonald, W. Hayes, Luo, Weifeng, Zhao, Ping, Coffey, Robert J., Hanks, Steven K., Manning, H. Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832668/
https://www.ncbi.nlm.nih.gov/pubmed/24260357
http://dx.doi.org/10.1371/journal.pone.0080207

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832668/
https://www.ncbi.nlm.nih.gov/pubmed/24260357
http://dx.doi.org/10.1371/journal.pone.0080207

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