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Extracellular adenosine regulates naive T cell development and peripheral maintenance

Adenosine produced as a byproduct of metabolic activity is present in all tissues and produces dose-dependent suppression of TCR signaling. Naive T cell maintenance depends on inhibition of TCR signals by environmental sensors, which are yet to be fully defined. We produced mice with a floxed adenos...

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Detalles Bibliográficos
Autores principales: Cekic, Caglar, Sag, Duygu, Day, Yuan-Ji, Linden, Joel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832923/
https://www.ncbi.nlm.nih.gov/pubmed/24145516
http://dx.doi.org/10.1084/jem.20130249