Cargando…

Concurrent loss of Ezh2 and Tet2 cooperates in the pathogenesis of myelodysplastic disorders

Polycomb group (PcG) proteins are essential regulators of hematopoietic stem cells. Recent extensive mutation analyses of the myeloid malignancies have revealed that inactivating somatic mutations in PcG genes such as EZH2 and ASXL1 occur frequently in patients with myelodysplastic disorders includi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Muto, Tomoya, Sashida, Goro, Oshima, Motohiko, Wendt, George R., Mochizuki-Kashio, Makiko, Nagata, Yasunobu, Sanada, Masashi, Miyagi, Satoru, Saraya, Atsunori, Kamio, Asuka, Nagae, Genta, Nakaseko, Chiaki, Yokote, Koutaro, Shimoda, Kazuya, Koseki, Haruhiko, Suzuki, Yutaka, Sugano, Sumio, Aburatani, Hiroyuki, Ogawa, Seishi, Iwama, Atsushi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832936/ https://www.ncbi.nlm.nih.gov/pubmed/24218139 http://dx.doi.org/10.1084/jem.20131144

Ejemplares similares

The loss of Ezh2 drives the pathogenesis of myelofibrosis and sensitizes tumor-initiating cells to bromodomain inhibition
por: Sashida, Goro, et al.
Publicado: (2016)

Ezh1 Targets Bivalent Genes to Maintain Self-Renewing Stem Cells in Ezh2-Insufficient Myelodysplastic Syndrome
por: Aoyama, Kazumasa, et al.
Publicado: (2018)

Non-Lethal Ionizing Radiation Promotes Aging-Like Phenotypic Changes of Human Hematopoietic Stem and Progenitor Cells in Humanized Mice
por: Wang, Changshan, et al.
Publicado: (2015)

Bmi1 Confers Resistance to Oxidative Stress on Hematopoietic Stem Cells
por: Nakamura, Shunsuke, et al.
Publicado: (2012)

The TIF1β-HP1 System Maintains Transcriptional Integrity of Hematopoietic Stem Cells
por: Miyagi, Satoru, et al.
Publicado: (2014)

TET1 upregulation drives cancer cell growth through aberrant enhancer hydroxymethylation of HMGA2 in hepatocellular carcinoma
por: Shirai, Kiyokazu, et al.
Publicado: (2021)

A Novel Zinc Finger Protein Zfp277 Mediates Transcriptional Repression of the Ink4a/Arf Locus through Polycomb Repressive Complex 1
por: Negishi, Masamitsu, et al.
Publicado: (2010)

Loss of Pcgf5 Affects Global H2A Monoubiquitination but Not the Function of Hematopoietic Stem and Progenitor Cells
por: Si, Sha, et al.
Publicado: (2016)

Internal deletion of BCOR reveals a tumor suppressor function for BCOR in T lymphocyte malignancies
por: Tanaka, Tomoyuki, et al.
Publicado: (2017)

Exposure to microbial products followed by loss of Tet2 promotes myelodysplastic syndrome via remodeling HSCs
por: Yokomizo-Nakano, Takako, et al.
Publicado: (2023)

Generation of Mouse Primitive Endoderm Stem Cells
por: Ohinata, Yasuhide, et al.
Publicado: (2023)

Gene expression profiling of loss of TET2 and/or JAK2V617F mutant hematopoietic stem cells from mouse models of myeloproliferative neoplasms
por: Kameda, Takuro, et al.
Publicado: (2015)

Reduced TET2 function leads to T-cell lymphoma with follicular helper T-cell-like features in mice
por: Muto, H, et al.
Publicado: (2014)

The combination of the tubulin binding small molecule PTC596 and proteasome inhibitors suppresses the growth of myeloma cells
por: Nagai, Yurie, et al.
Publicado: (2021)

Lethal myelofibrosis induced by Bmi1-deficient hematopoietic cells unveils a tumor suppressor function of the polycomb group genes
por: Oguro, Hideyuki, et al.
Publicado: (2012)

TET2 functions as a resistance factor against DNA methylation acquisition during Epstein-Barr virus infection
por: Namba-Fukuyo, Hiroe, et al.
Publicado: (2016)

Genome-Wide Mapping of Bivalent Histone Modifications in Hepatic Stem/Progenitor Cells
por: Kanayama, Kengo, et al.
Publicado: (2019)

Molecular Evolution of the TET Gene Family in Mammals
por: Akahori, Hiromichi, et al.
Publicado: (2015)

Genome‐wide analysis of DNA methylation identifies the apoptosis‐related gene UQCRH as a tumor suppressor in renal cancer
por: Miyakuni, Kosuke, et al.
Publicado: (2021)

Polycomb repressive complex 1.1 coordinates homeostatic and emergency myelopoiesis
por: Nakajima-Takagi, Yaeko, et al.
Publicado: (2023)

Extramedullary blast crisis of chronic myelogenous leukemia as an initial presentation()
por: Tsukamoto, Shokichi, et al.
Publicado: (2013)

DNA Methylation Profiling of Embryonic Stem Cell Differentiation into the Three Germ Layers
por: Isagawa, Takayuki, et al.
Publicado: (2011)

Spatial and temporal expansion of intrahepatic metastasis by molecularly‐defined clonality in multiple liver cancers
por: Yamamoto, Shogo, et al.
Publicado: (2020)

Akt inhibition synergizes with polycomb repressive complex 2 inhibition in the treatment of multiple myeloma
por: Rizk, Mohamed, et al.
Publicado: (2019)

Disulfiram Eradicates Tumor-Initiating Hepatocellular Carcinoma Cells in ROS-p38 MAPK Pathway-Dependent and -Independent Manners
por: Chiba, Tetsuhiro, et al.
Publicado: (2014)

Epithelial–Mesenchymal Transition in Liver Fluke-Induced Cholangiocarcinoma
por: Sawanyawisuth, Kanlayanee, et al.
Publicado: (2021)

Is obesity an absolute evil? Increase in adipose tissue does not always decrease insulin sensitivity
por: Ishikawa, Ko, et al.
Publicado: (2014)

Time to consider an Asian guideline for management of dyslipidemia?
por: Yokote, Koutaro, et al.
Publicado: (2012)

Human glomerular transcriptome of diabetic kidneys: Can the podocyte cytoskeleton be a therapeutic target?
por: Maezawa, Yoshiro, et al.
Publicado: (2018)

Novel mechanism of increasing cerebral vascular constriction in acute hyperglycemia and diabetes through adenylyl cyclase 5‐generated cyclic adenosine monophosphate
por: Sakamoto, Kenichi, et al.
Publicado: (2019)

Can we catch the second loach employing BACE1 inhibition, even as the first one might be escaping?
por: Ono, Hiraku, et al.
Publicado: (2021)

Fibroblasts from different body parts exhibit distinct phenotypes in adult progeria Werner syndrome
por: Kato, Hisaya, et al.
Publicado: (2021)

Novel myocardial markers GADD45G and NDUFS5 identified by RNA-sequencing predicts left ventricular reverse remodeling in advanced non-ischemic heart failure: a retrospective cohort study
por: Iwahana, Togo, et al.
Publicado: (2020)

Activation of Bmp2-Smad1 Signal and Its Regulation by Coordinated Alteration of H3K27 Trimethylation in Ras-Induced Senescence
por: Kaneda, Atsushi, et al.
Publicado: (2011)

Werner Syndrome-specific induced pluripotent stem cells: recovery of telomere function by reprogramming
por: Shimamoto, Akira, et al.
Publicado: (2015)

Cell biology of diabetic nephropathy: Roles of endothelial cells, tubulointerstitial cells and podocytes
por: Maezawa, Yoshiro, et al.
Publicado: (2015)

Updates on dyslipidemia in patients with diabetes
por: Ide, Shintaro, et al.
Publicado: (2023)

Endogenous epitope-tagging of Tet1, Tet2 and Tet3 identifies TET2 as a naïve pluripotency marker
por: Pantier, Raphaël, et al.
Publicado: (2019)

Author Correction: Lineage-specific RUNX2 super-enhancer activates MYC and promotes the development of blastic plasmacytoid dendritic cell neoplasm
por: Kubota, Sho, et al.
Publicado: (2019)

Lineage-specific RUNX2 super-enhancer activates MYC and promotes the development of blastic plasmacytoid dendritic cell neoplasm
por: Kubota, Sho, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_rm8tuvcmflhaehc0ujsal64g9a