SILAC-based phosphoproteomics reveals an inhibitory role of KSR1 in p53 transcriptional activity via modulation of DBC1

BACKGROUND: We have previously identified kinase suppressor of ras-1 (KSR1) as a potential regulatory gene in breast cancer. KSR1, originally described as a novel protein kinase, has a role in activation of mitogen-activated protein kinases. Emerging evidence has shown that KSR1 may have dual functi...

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Detalles Bibliográficos
Autores principales: Zhang, H, Xu, Y, Filipovic, A, Lit, L C, Koo, C-Y, Stebbing, J, Giamas, G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833216/
https://www.ncbi.nlm.nih.gov/pubmed/24129246
http://dx.doi.org/10.1038/bjc.2013.628

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833216/
https://www.ncbi.nlm.nih.gov/pubmed/24129246
http://dx.doi.org/10.1038/bjc.2013.628

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