Cargando…

ALK gene amplification is associated with poor prognosis in colorectal carcinoma

BACKGROUND: Recently, the anaplastic lymphoma kinase (ALK) has been found to be altered in several solid and haematological tumours. ALK gene copy number changes and mutations in colorectal cancers (CRCs) are not well characterised. We aimed to study the prevalence of ALK copy number changes, transl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bavi, P, Jehan, Z, Bu, R, Prabhakaran, S, Al-Sanea, N, Al-Dayel, F, Al-Assiri, M, Al-Halouly, T, Sairafi, R, Uddin, S, Al-Kuraya, K S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Genetics and Genomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833224/ https://www.ncbi.nlm.nih.gov/pubmed/24129244 http://dx.doi.org/10.1038/bjc.2013.641

Ejemplares similares

A very low incidence of BRAF mutations in Middle Eastern colorectal carcinoma
por: Siraj, Abdul K, et al.
Publicado: (2014)

Phosphorylated IκBα Predicts Poor Prognosis in Activated B-Cell Lymphoma and Its Inhibition with Thymoquinone Induces Apoptosis via ROS Release
por: Hussain, Azhar R., et al.
Publicado: (2013)

Prognostic significance of TRAIL death receptors in Middle Eastern colorectal carcinomas and their correlation to oncogenic KRAS alterations
por: Bavi, Prashant, et al.
Publicado: (2010)

Clinico-pathological significance of TNF alpha-induced protein3 (TNFAIP3) in Middle Eastern colorectal carcinoma
por: Bavi, Prashant, et al.
Publicado: (2011)

Co-targeting of Cyclooxygenase-2 and FoxM1 is a viable strategy in inducing anticancer effects in colorectal cancer cells
por: Ahmed, Maqbool, et al.
Publicado: (2015)

ALK alteration is a frequent event in aggressive breast cancers
por: Siraj, Abdul K., et al.
Publicado: (2015)

Overexpression of leptin receptor predicts an unfavorable outcome in Middle Eastern ovarian cancer
por: Uddin, Shahab, et al.
Publicado: (2009)

PD-L1 Expression Is Associated with Deficient Mismatch Repair and Poor Prognosis in Middle Eastern Colorectal Cancers
por: Siraj, Abdul K., et al.
Publicado: (2021)

MMP7 Polymorphisms - A New Tool in Molecular Pathology to Understand Esophageal Cancer
por: Bavi, Prashant P., et al.
Publicado: (2011)

PIK3CA alterations in Middle Eastern ovarian cancers
por: Abubaker, Jehad, et al.
Publicado: (2009)

MED12 is recurrently mutated in Middle Eastern colorectal cancer
por: Siraj, Abdul K, et al.
Publicado: (2018)

Polymorphisms of selected Xenobiotic Genes contribute to the development of Papillary Thyroid Cancer susceptibility in Middle Eastern population
por: Siraj, Abdul K, et al.
Publicado: (2008)

Identification of novel BRCA founder mutations in Middle Eastern breast cancer patients using capture and Sanger sequencing analysis
por: Bu, Rong, et al.
Publicado: (2016)

PTEN loss is associated with follicular variant of Middle Eastern papillary thyroid carcinoma
por: Beg, S, et al.
Publicado: (2015)

An inherited NBN mutation is associated with poor prognosis prostate cancer
por: Cybulski, C, et al.
Publicado: (2013)

SUN-132 KLF5 Is a Poor Prognostic Marker and Therapeutic Target for Middle Eastern Papillary Thyroid Carcinoma
por: Al-Kuraya, Khawla S, et al.
Publicado: (2020)

Nuclear oxidative damage correlates with poor survival in colorectal cancer
por: Sheridan, J, et al.
Publicado: (2009)

Wild-type APC predicts poor prognosis in microsatellite-stable proximal colon cancer
por: Jorissen, Robert N, et al.
Publicado: (2015)

DLEC1 and MLH1 promoter methylation are associated with poor prognosis in non-small cell lung carcinoma
por: Seng, T J, et al.
Publicado: (2008)

Amplification of the CD24 Gene Is an Independent Predictor for Poor Prognosis of Breast Cancer
por: Zhang, Peng, et al.
Publicado: (2019)

XIAP over-expression is an independent poor prognostic marker in Middle Eastern breast cancer and can be targeted to induce efficient apoptosis
por: Hussain, Azhar R., et al.
Publicado: (2017)

Genetic diversity of the Nubian ibex in Oman as revealed by mitochondrial DNA
por: Al-Ghafri, Mataab K., et al.
Publicado: (2021)

Rescued back from extinction in the wild: past, present and future of the genetics of the Arabian oryx in Oman
por: Al Rawahi, Qais, et al.
Publicado: (2022)

Disseminated tumour cells with highly aberrant genomes are linked to poor prognosis in operable oesophageal adenocarcinoma
por: Schumacher, Sarah, et al.
Publicado: (2017)

Exome sequencing revealed comparable frequencies of RNF43 and BRAF mutations in Middle Eastern colorectal cancer
por: Siraj, Abdul Khalid, et al.
Publicado: (2022)

A Network-Based Methodology to Identify Subnetwork Markers for Diagnosis and Prognosis of Colorectal Cancer
por: Al-Harazi, Olfat, et al.
Publicado: (2021)

High level of telomerase RNA gene expression is associated with chromatin modification, the ALT phenotype and poor prognosis in liposarcoma
por: Cairney, C J, et al.
Publicado: (2008)

KRAS and TP53 Mutations in Colorectal Carcinoma
por: Al-Kuraya, Khawla S.
Publicado: (2009)

Disentangling the interplay of positive and negative selection forces that shaped mitochondrial genomes of Gammarus pisinnus and Gammarus lacustris
por: Sun, Shengming, et al.
Publicado: (2020)

Recurrent Somatic MAP2K1 Mutations in Papillary Thyroid Cancer and Colorectal Cancer
por: Bu, Rong, et al.
Publicado: (2021)

Overexpression of PARP is an independent prognostic marker for poor survival in Middle Eastern breast cancer and its inhibition can be enhanced with embelin co-treatment
por: Siraj, Abdul Khalid, et al.
Publicado: (2018)

Whole Exome-Wide Association Identifies Rare Variants in GALNT9 Associated with Middle Eastern Papillary Thyroid Carcinoma Risk
por: Bu, Rong, et al.
Publicado: (2023)

Loss of ZNF677 expression is a predictive biomarker for lymph node metastasis in Middle Eastern Colorectal Cancer
por: Siraj, Abdul K., et al.
Publicado: (2021)

Endogenous BTG2 expression stimulates migration of bladder cancer cells and correlates with poor clinical prognosis for bladder cancer patients
por: Wagener, N, et al.
Publicado: (2013)

Tau polarizes an aging transcriptional signature to excitatory neurons and glia
por: Wu, Timothy, et al.
Publicado: (2023)

KRAS gene amplification and overexpression but not mutation associates with aggressive and metastatic endometrial cancer
por: Birkeland, E, et al.
Publicado: (2012)

Transcriptomic data analysis coupled with copy number aberrations reveals a blood-based 17-gene signature for diagnosis and prognosis of patients with colorectal cancer
por: Kaya, Ibrahim H., et al.
Publicado: (2023)

FoxM1 is an independent poor prognostic marker and therapeutic target for advanced Middle Eastern breast cancer
por: Siraj, Abdul Khalid, et al.
Publicado: (2018)

High Expression of FCRLB Predicts Poor Prognosis in Patients With Colorectal Cancer
por: Wang, Xiaopeng, et al.
Publicado: (2022)

5′ ALK Amplification in Neuroblastoma: A Case Report
por: Akhavanfard, Sara, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_cp6lnnm8q5f0p21trv4d6bb4e8