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Silencing NOTCH signaling causes growth arrest in both breast cancer stem cells and breast cancer cells

BACKGROUND: Breast cancer stem cells (BCSCs) are characterized by high aldehyde dehydrogenase (ALDH) enzyme activity and are refractory to current treatment modalities, show a higher risk for metastasis, and influence the epithelial to mesenchymal transition (EMT), leading to a shorter time to recur...

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Detalles Bibliográficos
Autores principales:	Suman, S, Das, T P, Damodaran, C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Translational Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833225/ https://www.ncbi.nlm.nih.gov/pubmed/24129237 http://dx.doi.org/10.1038/bjc.2013.642

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