De Novo Design of Protein Kinase Inhibitors by in Silico Identification of Hinge Region-Binding Fragments

[Image: see text] Protein kinases constitute an attractive family of enzyme targets with high relevance to cell and disease biology. Small molecule inhibitors are powerful tools to dissect and elucidate the function of kinases in chemical biology research and to serve as potential starting points fo...

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Detalles Bibliográficos
Autores principales: Urich, Robert, Wishart, Grant, Kiczun, Michael, Richters, André, Tidten-Luksch, Naomi, Rauh, Daniel, Sherborne, Brad, Wyatt, Paul G., Brenk, Ruth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2013
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833278/
https://www.ncbi.nlm.nih.gov/pubmed/23534475
http://dx.doi.org/10.1021/cb300729y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833278/
https://www.ncbi.nlm.nih.gov/pubmed/23534475
http://dx.doi.org/10.1021/cb300729y

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