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De Novo Design of Protein Kinase Inhibitors by in Silico Identification of Hinge Region-Binding Fragments
[Image: see text] Protein kinases constitute an attractive family of enzyme targets with high relevance to cell and disease biology. Small molecule inhibitors are powerful tools to dissect and elucidate the function of kinases in chemical biology research and to serve as potential starting points fo...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American
Chemical Society
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833278/ https://www.ncbi.nlm.nih.gov/pubmed/23534475 http://dx.doi.org/10.1021/cb300729y |