microRNA-1 regulates sarcomere formation and suppresses smooth muscle gene expression in the mammalian heart

microRNA-1 (miR-1) is an evolutionarily conserved, striated muscle-enriched miRNA. Most mammalian genomes contain two copies of miR-1, and in mice, deletion of a single locus, miR-1-2, causes incompletely penetrant lethality and subtle cardiac defects. Here, we report that deletion of miR-1-1 result...

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Detalles Bibliográficos
Autores principales: Heidersbach, Amy, Saxby, Chris, Carver-Moore, Karen, Huang, Yu, Ang, Yen-Sin, de Jong, Pieter J, Ivey, Kathryn N, Srivastava, Deepak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2013
Materias:
Developmental Biology and Stem Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833424/
https://www.ncbi.nlm.nih.gov/pubmed/24252873
http://dx.doi.org/10.7554/eLife.01323

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833424/
https://www.ncbi.nlm.nih.gov/pubmed/24252873
http://dx.doi.org/10.7554/eLife.01323

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