Caspase cleavage of GFAP produces an assembly-compromised proteolytic fragment that promotes filament aggregation

IF (intermediate filament) proteins can be cleaved by caspases to generate proapoptotic fragments as shown for desmin. These fragments can also cause filament aggregation. The hypothesis is that disease-causing mutations in IF proteins and their subsequent characteristic histopathological aggregates...

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Detalles Bibliográficos
Autores principales: Chen, Mei-Hsuan, Hagemann, Tracy L., Quinlan, Roy A., Messing, Albee, Perng, Ming-Der
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Neurochemistry 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833455/
https://www.ncbi.nlm.nih.gov/pubmed/24102621
http://dx.doi.org/10.1042/AN20130032

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833455/
https://www.ncbi.nlm.nih.gov/pubmed/24102621
http://dx.doi.org/10.1042/AN20130032

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