In Silico Molecular Comparisons of C. elegans and Mammalian Pharmacology Identify Distinct Targets That Regulate Feeding

Phenotypic screens can identify molecules that are at once penetrant and active on the integrated circuitry of a whole cell or organism. These advantages are offset by the need to identify the targets underlying the phenotypes. Additionally, logistical considerations limit screening for certain phys...

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Detalles Bibliográficos
Autores principales: Lemieux, George A., Keiser, Michael J., Sassano, Maria F., Laggner, Christian, Mayer, Fahima, Bainton, Roland J., Werb, Zena, Roth, Bryan L., Shoichet, Brian K., Ashrafi, Kaveh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833878/
https://www.ncbi.nlm.nih.gov/pubmed/24260022
http://dx.doi.org/10.1371/journal.pbio.1001712

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833878/
https://www.ncbi.nlm.nih.gov/pubmed/24260022
http://dx.doi.org/10.1371/journal.pbio.1001712

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