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TNF-mediated damage to glomerular endothelium is an important determinant of acute kidney injury in sepsis

Severe sepsis is often accompanied by acute kidney injury (AKI) and albuminuria. Here we studied whether the AKI and albuminuria associated with lipopolysaccharide (LPS) treatment in mice reflects impairment of the glomerular endothelium with its associated endothelial surface layer. LPS treatment d...

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Detalles Bibliográficos
Autores principales: Xu, Chang, Chang, Anthony, Hack, Bradley K., Eadon, Michael T., Alper, Seth L., Cunningham, Patrick N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834073/
https://www.ncbi.nlm.nih.gov/pubmed/23903370
http://dx.doi.org/10.1038/ki.2013.286