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Hypoxia reduces CD138 expression and induces an immature and stem cell-like transcriptional program in myeloma cells

Although CD138 expression is a hallmark of plasma cells and myeloma cells, reduced CD138 expression is occasionally found. However, the mechanisms underlying CD138 downregulation in myeloma cells remain unclear. Previous reports suggest that the bone marrow microenvironment may contribute to CD138 d...

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Detalles Bibliográficos
Autores principales: KAWANO, YAWARA, KIKUKAWA, YOSHITAKA, FUJIWARA, SHIHO, WADA, NAOKO, OKUNO, YUTAKA, MITSUYA, HIROAKI, HATA, HIROYUKI
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834117/
https://www.ncbi.nlm.nih.gov/pubmed/24126540
http://dx.doi.org/10.3892/ijo.2013.2134