BRD4 Short Isoform Interacts with RRP1B, SIPA1 and Components of the LINC Complex at the Inner Face of the Nuclear Membrane

Recent studies suggest that BET inhibitors are effective anti-cancer therapeutics. Here we show that BET inhibitors are effective against murine primary mammary tumors, but not pulmonary metastases. BRD4, a target of BET inhibitors, encodes two isoforms with opposite effects on tumor progression. To...

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Detalles Bibliográficos
Autores principales: Alsarraj, Jude, Faraji, Farhoud, Geiger, Thomas R., Mattaini, Katherine R., Williams, Mia, Wu, Josephine, Ha, Ngoc-Han, Merlino, Tyler, Walker, Renard C., Bosley, Allen D., Xiao, Zhen, Andresson, Thorkell, Esposito, Dominic, Smithers, Nicholas, Lugo, Dave, Prinjha, Rab, Day, Anup, Crawford, Nigel P. S., Ozato, Keiko, Gardner, Kevin, Hunter, Kent W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834312/
https://www.ncbi.nlm.nih.gov/pubmed/24260471
http://dx.doi.org/10.1371/journal.pone.0080746

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834312/
https://www.ncbi.nlm.nih.gov/pubmed/24260471
http://dx.doi.org/10.1371/journal.pone.0080746

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