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JAK3 inhibition: what potential for the future?
JAK3 inhibition with the CP-690,550 compound has an immunosuppressive potency in murine models, nonhuman primates and humans. This drug blocks STAT5 activation in most T-cell subpopulations but less effectively in T-regulator cells. In low to moderate risk human kidney transplant recipients, combine...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834527/ https://www.ncbi.nlm.nih.gov/pubmed/24565406 http://dx.doi.org/10.1186/2047-1440-2-S1-S6 |