The Interleukin-1α Precursor is Biologically Active and is Likely a Key Alarmin in the IL-1 Family of Cytokines

Among the 11 members of the IL-1 family cytokines, the precursors of IL-1α, IL-1β, and IL-33 have relatively long N-terminal pro-sequences of approximately 100 amino acid residues prior to the N-terminus of the mature forms. Compared to the mature forms secreted from the cell, 80–90% of the primary...

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Detalles Bibliográficos
Autores principales: Kim, Busun, Lee, Youngmin, Kim, Eunsom, Kwak, Areum, Ryoo, Soyoon, Bae, Seung Hyeon, Azam, Tania, Kim, Soohyun, Dinarello, Charles A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834611/
https://www.ncbi.nlm.nih.gov/pubmed/24312098
http://dx.doi.org/10.3389/fimmu.2013.00391

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834611/
https://www.ncbi.nlm.nih.gov/pubmed/24312098
http://dx.doi.org/10.3389/fimmu.2013.00391

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