Adjusting scoring matrices to correct overextended alignments

Motivation: Sequence similarity searches performed with BLAST, SSEARCH and FASTA achieve high sensitivity by using scoring matrices (e.g. BLOSUM62) that target low identity (<33%) alignments. Although such scoring matrices can effectively identify distant homologs, they can also produce local ali...

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Detalles Bibliográficos
Autores principales: Mills, Lauren J., Pearson, William R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834790/
https://www.ncbi.nlm.nih.gov/pubmed/23995390
http://dx.doi.org/10.1093/bioinformatics/btt517

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834790/
https://www.ncbi.nlm.nih.gov/pubmed/23995390
http://dx.doi.org/10.1093/bioinformatics/btt517

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