Structure of an ‘open’ clamp type II topoisomerase-DNA complex provides a mechanism for DNA capture and transport

Type II topoisomerases regulate DNA supercoiling and chromosome segregation. They act as ATP-operated clamps that capture a DNA duplex and pass it through a transient DNA break in a second DNA segment via the sequential opening and closure of ATPase-, G-DNA- and C-gates. Here, we present the first ‘...

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Detalles Bibliográficos
Autores principales: Laponogov, Ivan, Veselkov, Dennis A., Crevel, Isabelle M.-T., Pan, Xiao-Su, Fisher, L. Mark, Sanderson, Mark R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834822/
https://www.ncbi.nlm.nih.gov/pubmed/23965305
http://dx.doi.org/10.1093/nar/gkt749

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834822/
https://www.ncbi.nlm.nih.gov/pubmed/23965305
http://dx.doi.org/10.1093/nar/gkt749

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