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Directed evolution of the TALE N-terminal domain for recognition of all 5′ bases
Transcription activator-like effector (TALE) proteins can be designed to bind virtually any DNA sequence. General guidelines for design of TALE DNA-binding domains suggest that the 5′-most base of the DNA sequence bound by the TALE (the N(0) base) should be a thymine. We quantified the N(0) requirem...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834825/ https://www.ncbi.nlm.nih.gov/pubmed/23980031 http://dx.doi.org/10.1093/nar/gkt754 |