Preparation and Characterization of Amino Acids-Based Trimethoprim Salts

Trimethoprim (TMP) is a dihydrofolate reductase (DHFR) inhibitor which prevents the conversion of dihydrofolic acid into tetrahydrofolic acid, resulting in the depletion of the latter and leading to bacterial death. Oral bioavailability of TMP is hindered by both its low solubility and low permeabil...

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Detalles Bibliográficos
Autores principales: ElShaer, Amr, Hanson, Peter, Worthington, Tony, Lambert, Peter, Mohammed, Afzal R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834905/
https://www.ncbi.nlm.nih.gov/pubmed/24300187
http://dx.doi.org/10.3390/pharmaceutics4010179

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834905/
https://www.ncbi.nlm.nih.gov/pubmed/24300187
http://dx.doi.org/10.3390/pharmaceutics4010179

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