Nrf2 and NF-κB and Their Concerted Modulation in Cancer Pathogenesis and Progression

Reactive oxygen species, produced by oxidative stress, are implicated in the initiation, promotion, and malignant conversion of carcinogenesis through activation/suppression of redox-sensitive transcription factors. NF-E2-related factor 2 (Nrf2) encodes for antioxidant and general cytoprotection gen...

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Detalles Bibliográficos
Autores principales: Bellezza, Ilaria, Mierla, Anna Lisa, Minelli, Alba
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835087/
https://www.ncbi.nlm.nih.gov/pubmed/24281078
http://dx.doi.org/10.3390/cancers2020483
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author Bellezza, Ilaria
Mierla, Anna Lisa
Minelli, Alba
author_facet Bellezza, Ilaria
Mierla, Anna Lisa
Minelli, Alba
author_sort Bellezza, Ilaria
collection PubMed
description Reactive oxygen species, produced by oxidative stress, are implicated in the initiation, promotion, and malignant conversion of carcinogenesis through activation/suppression of redox-sensitive transcription factors. NF-E2-related factor 2 (Nrf2) encodes for antioxidant and general cytoprotection genes, while NF-κB regulates the expression of pro-inflammatory genes. A variety of anti-inflammatory or anti-carcinogenic phyto-chemicals suppress NF-κB signalling and activate the Nrf2-ARE pathway. In this review we consider the role of Nrf2 and NF-κB in cancer pathogenesis and progression, focusing on their concerted modulation and potential cross-talk.
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spelling pubmed-38350872013-11-21 Nrf2 and NF-κB and Their Concerted Modulation in Cancer Pathogenesis and Progression Bellezza, Ilaria Mierla, Anna Lisa Minelli, Alba Cancers (Basel) Review Reactive oxygen species, produced by oxidative stress, are implicated in the initiation, promotion, and malignant conversion of carcinogenesis through activation/suppression of redox-sensitive transcription factors. NF-E2-related factor 2 (Nrf2) encodes for antioxidant and general cytoprotection genes, while NF-κB regulates the expression of pro-inflammatory genes. A variety of anti-inflammatory or anti-carcinogenic phyto-chemicals suppress NF-κB signalling and activate the Nrf2-ARE pathway. In this review we consider the role of Nrf2 and NF-κB in cancer pathogenesis and progression, focusing on their concerted modulation and potential cross-talk. Molecular Diversity Preservation International 2010-04-13 /pmc/articles/PMC3835087/ /pubmed/24281078 http://dx.doi.org/10.3390/cancers2020483 Text en © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Bellezza, Ilaria
Mierla, Anna Lisa
Minelli, Alba
Nrf2 and NF-κB and Their Concerted Modulation in Cancer Pathogenesis and Progression
title Nrf2 and NF-κB and Their Concerted Modulation in Cancer Pathogenesis and Progression
title_full Nrf2 and NF-κB and Their Concerted Modulation in Cancer Pathogenesis and Progression
title_fullStr Nrf2 and NF-κB and Their Concerted Modulation in Cancer Pathogenesis and Progression
title_full_unstemmed Nrf2 and NF-κB and Their Concerted Modulation in Cancer Pathogenesis and Progression
title_short Nrf2 and NF-κB and Their Concerted Modulation in Cancer Pathogenesis and Progression
title_sort nrf2 and nf-κb and their concerted modulation in cancer pathogenesis and progression
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835087/
https://www.ncbi.nlm.nih.gov/pubmed/24281078
http://dx.doi.org/10.3390/cancers2020483
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