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Conditional Knockout of Myocyte Focal Adhesion Kinase Abrogates Ischemic Preconditioning in Adult Murine Hearts

BACKGROUND: Our laboratory has previously demonstrated the importance of a cytoskeletal‐based survival signaling pathway using in vitro models of ischemia/reperfusion (IR). However, the importance of this pathway in mediating stress‐elicited survival signaling in vivo is unknown. METHODS AND RESULTS...

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Detalles Bibliográficos
Autores principales: Perricone, Adam J., Bivona, Benjamin J., Jackson, Fannie R., Vander Heide, Richard S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835261/
https://www.ncbi.nlm.nih.gov/pubmed/24080910
http://dx.doi.org/10.1161/JAHA.113.000457