Modeling Alzheimer’s Disease in Mouse without Mutant Protein Overexpression: Cooperative and Independent Effects of Aβ and Tau

BACKGROUND: Alzheimer’s disease (AD), the most common cause of dementia in the elderly, has two pathological hallmarks: Aβ plaques and aggregation of hyperphosphorylated tau (p-tau). Aβ is a cleavage product of Amyloid Precursor Protein (APP). Presenilin 1 (PS1) and presenilin 2 (PS2) are the cataly...

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Detalles Bibliográficos
Autores principales: Guo, Qinxi, Li, Hongmei, Cole, Allysa L., Hur, Ji-Yeun, Li, Yueming, Zheng, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835479/
https://www.ncbi.nlm.nih.gov/pubmed/24278307
http://dx.doi.org/10.1371/journal.pone.0080706

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835479/
https://www.ncbi.nlm.nih.gov/pubmed/24278307
http://dx.doi.org/10.1371/journal.pone.0080706

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