Acetate Supplementation Induces Growth Arrest of NG2/PDGFRα-Positive Oligodendroglioma-Derived Tumor-Initiating Cells

Cancer is associated with globally hypoacetylated chromatin and considerable attention has recently been focused on epigenetic therapies. N-acetyl-L-aspartate (NAA), the primary storage form of acetate in the brain, and aspartoacylase (ASPA), the enzyme responsible for NAA catalysis to generate acet...

Descripción completa

Detalles Bibliográficos
Autores principales: Long, Patrick M., Tighe, Scott W., Driscoll, Heather E., Moffett, John R., Namboodiri, Aryan M. A., Viapiano, Mariano S., Lawler, Sean E., Jaworski, Diane M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835562/
https://www.ncbi.nlm.nih.gov/pubmed/24278309
http://dx.doi.org/10.1371/journal.pone.0080714

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835562/
https://www.ncbi.nlm.nih.gov/pubmed/24278309
http://dx.doi.org/10.1371/journal.pone.0080714

Ejemplares similares