Binding, Transcytosis and Biodistribution of Anti-PECAM-1 Iron Oxide Nanoparticles for Brain-Targeted Delivery

OBJECTIVE: Characterize the flux of platelet-endothelial cell adhesion molecule (PECAM-1) antibody-coated superparamagnetic iron oxide nanoparticles (IONPs) across the blood-brain barrier (BBB) and its biodistribution in vitro and in vivo. METHODS: Anti-PECAM-1 IONPs and IgG IONPs were prepared and...

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Detalles Bibliográficos
Autores principales: Dan, Mo, Cochran, David B., Yokel, Robert A., Dziubla, Thomas D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835573/
https://www.ncbi.nlm.nih.gov/pubmed/24278373
http://dx.doi.org/10.1371/journal.pone.0081051

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835573/
https://www.ncbi.nlm.nih.gov/pubmed/24278373
http://dx.doi.org/10.1371/journal.pone.0081051

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