Non-Invasive Imaging of Tumors by Monitoring Autotaxin Activity Using an Enzyme-Activated Near-Infrared Fluorogenic Substrate

Autotaxin (ATX), an autocrine motility factor that is highly upregulated in metastatic cancer, is a lysophospholipase D enzyme that produces the lipid second messenger lysophosphatidic acid (LPA) from lysophosphatidylcholine (LPC). Dysregulation of the lysolipid signaling pathway is central to the p...

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Detalles Bibliográficos
Autores principales: Madan, Damian, Ferguson, Colin G., Lee, Won Yong, Prestwich, Glenn D., Testa, Charles A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835791/
https://www.ncbi.nlm.nih.gov/pubmed/24278115
http://dx.doi.org/10.1371/journal.pone.0079065

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835791/
https://www.ncbi.nlm.nih.gov/pubmed/24278115
http://dx.doi.org/10.1371/journal.pone.0079065

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