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Phenotypic and Transcriptional Fidelity of Patient-Derived Colon Cancer Xenografts in Immune-Deficient Mice

Xenografts of human colorectal cancer (CRC) in immune-deficient mice have great potential for accelerating the study of tumor biology and therapy. We evaluated xenografts established in NOD/scid/IL2Rγ-null mice from the primary or metastatic tumors of 27 patients with CRC to estimate their capacity...

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Detalles Bibliográficos
Autores principales: Chou, Jeffrey, Fitzgibbon, Matthew P., Mortales, Christie-Lynn L., Towlerton, Andrea M. H., Upton, Melissa P., Yeung, Raymond S., McIntosh, Martin W., Warren, Edus H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835935/
https://www.ncbi.nlm.nih.gov/pubmed/24278200
http://dx.doi.org/10.1371/journal.pone.0079874