Cargando…

Phenotypic and Transcriptional Fidelity of Patient-Derived Colon Cancer Xenografts in Immune-Deficient Mice

Xenografts of human colorectal cancer (CRC) in immune-deficient mice have great potential for accelerating the study of tumor biology and therapy. We evaluated xenografts established in NOD/scid/IL2Rγ-null mice from the primary or metastatic tumors of 27 patients with CRC to estimate their capacity...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chou, Jeffrey, Fitzgibbon, Matthew P., Mortales, Christie-Lynn L., Towlerton, Andrea M. H., Upton, Melissa P., Yeung, Raymond S., McIntosh, Martin W., Warren, Edus H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835935/ https://www.ncbi.nlm.nih.gov/pubmed/24278200 http://dx.doi.org/10.1371/journal.pone.0079874

Ejemplares similares

Integrated TCR repertoire analysis and single-cell transcriptomic profiling of tumor-infiltrating T cells in renal cell carcinoma identifies shared and tumor-restricted expanded clones with unique phenotypes
por: Xu, Yuexin, et al.
Publicado: (2022)

Serial Analysis of the T-Cell Receptor β-Chain Repertoire in People Living With HIV Reveals Incomplete Recovery After Long-Term Antiretroviral Therapy
por: Towlerton, Andrea M. H., et al.
Publicado: (2022)

Immune escape from NY-ESO-1-specific T cell therapy via loss of heterozygosity in the MHC
por: Klippel, Zandra K., et al.
Publicado: (2014)

Preclinical development of T-cell receptor-engineered T-cell therapy targeting the 5T4 tumor antigen on renal cell carcinoma
por: Xu, Yuexin, et al.
Publicado: (2019)

Ultradeep, targeted sequencing reveals distinct mutations in blood compared to matched bone marrow among patients with multiple myeloma
por: Coffey, David G., et al.
Publicado: (2019)

Glycolysis and glutaminolysis cooperatively control T cell function by limiting metabolite supply to N-glycosylation
por: Araujo, Lindsey, et al.
Publicado: (2017)

N-Glycan Branching Decouples B Cell Innate and Adaptive Immunity to Control Inflammatory Demyelination
por: Mortales, Christie-Lynn, et al.
Publicado: (2020)

Golgi self-correction generates bioequivalent glycans to preserve cellular homeostasis
por: Mkhikian, Haik, et al.
Publicado: (2016)

Patient-derived xenograft mouse models: A high fidelity tool for individualized medicine
por: Xu, Cong, et al.
Publicado: (2019)

Current status of antigen-specific T-cell immunotherapy for advanced renal-cell carcinoma
por: Xu, Yuexin, et al.
Publicado: (2021)

Increasing cell permeability of N-acetylglucosamine via 6-acetylation enhances capacity to suppress T-helper 1 (T(H)1)/T(H)17 responses and autoimmunity
por: Lee, Sung-Uk, et al.
Publicado: (2019)

Single cell atlas of kidney cancer endothelial cells reveals distinct expression profiles and phenotypes
por: Xu, Yuexin, et al.
Publicado: (2023)

Effects of cyclic-nucleotide derivatives on the growth of human colonic carcinoma xenografts and on cell production in the rat colonic crypt epithelium.
por: Tutton, P. J., et al.
Publicado: (1981)

De Cristóbal Colón a Fidel Castro : el Caribe, frontera imperial /
por: Bosch, Juan, 1909-2001
Publicado: (2010)

De Cristóbal Colón a Fidel Castro : el Caribe, frontera imperial /
por: Bosch, Juan, 1909-2001
Publicado: (2009)

A Human Minor Histocompatibility Antigen Resulting from Differential Expression due to a Gene Deletion
por: Murata, Makoto, et al.
Publicado: (2003)

High‐fidelity of non‐small cell lung cancer xenograft models derived from bronchoscopy‐guided biopsies
por: Fu, Shuai, et al.
Publicado: (2015)

Orthotopic xenografts of human melanoma and colonic and ovarian carcinoma in sheep to evaluate radioimmunotherapy.
por: Turner, J. H., et al.
Publicado: (1998)

Mechanisms of immune evasion and current status of checkpoint inhibitors in non‐small cell lung cancer
por: Qin, Angel, et al.
Publicado: (2016)

Fidelity of human ovarian cancer patient-derived xenografts in a partially humanized mouse model for preclinical testing of immunotherapies
por: Odunsi, Adekunle, et al.
Publicado: (2020)

Serial cytogenetic studies of human colonic tumour xenografts.
por: Reeves, B. R., et al.
Publicado: (1978)

Preliminary observations on the microdistribution of labelled antibodies in human colonic adenocarcinoma xenografts: relevance to microdosimetry.
por: Pedley, R. B., et al.
Publicado: (1990)

Plasma-derived proteomic biomarkers in human leukocyte antigen-haploidentical or human leukocyte antigen-matched bone marrow transplantation using post-transplantation cyclophosphamide
por: Kanakry, Christopher G., et al.
Publicado: (2017)

Case report: A persistently expanded T cell response in an exceptional responder to radiation and atezolizumab for metastatic non-small cell lung cancer
por: Coffey, David G., et al.
Publicado: (2022)

Integrative Proteomic Analysis of Serum and Peritoneal Fluids Helps Identify Proteins that Are Up-Regulated in Serum of Women with Ovarian Cancer
por: Amon, Lynn M., et al.
Publicado: (2010)

Fidelity
Publicado: (1864)

Fidelity
Publicado: (1879)

Fidelity
Publicado: (1873)

Genomic Profiling of Patient-Derived Colon Cancer Xenograft Models
por: Lee, Won-Suk, et al.
Publicado: (2014)

Resveratrol and Its Nanoformulation Attenuate Growth and the Angiogenesis of Xenograft and Orthotopic Colon Cancer Models
por: Sudha, Thangirala, et al.
Publicado: (2020)

Immune Deficiency, Thrombocytopenia and Osteomyelitis in Pediatric Patients
por: Clark, Charles R., et al.
Publicado: (1978)

Establishment of a high-fidelity patient-derived xenograft model for cervical cancer enables the evaluation of patient’s response to conventional and novel therapies
por: Liu, Liting, et al.
Publicado: (2023)

Regulation of cytochrome P450 gene expression in human colon and breast tumour xenografts.
por: Smith, G., et al.
Publicado: (1993)

Fidel Velázquez /
por: García, Clara Guadalupe
Publicado: (2002)

Fidel Castro
por: Castro, Fidel, 1926-2016
Publicado: (1985)

Habla Fidel /
por: Castro, Fidel, 1926-2016
Publicado: (1988)

Professional Fidelity
por: Parmele, L.
Publicado: (1871)

Effects of cytotoxic agents on TdR incorporation and growth delay in human colonic tumour xenografts.
por: Houghton, P. J., et al.
Publicado: (1977)

Establishment of Drug Resistance in Human Gastric and Colon Carcinoma Xenograft Lines
por: Satta, Tetsuya, et al.
Publicado: (1991)

Challenges in Stratifying the Molecular Variability of Patient-Derived Colon Tumor Xenografts
por: Cybulska, Magdalena, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_hfgi78pfbo5elsjev66pikb692